RecruitingEarly Phase 1NCT04987775

GWICTIC: NAC Mechanistic Study in Gulf War Veterans

Mechanisms of Oxidative Stress During N-Acetyl Cysteine (NAC) Supplementation in Veterans With Gulf War Illness (GWI)


Sponsor

Nova Southeastern University

Enrollment

170 participants

Start Date

Nov 30, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.


Eligibility

Min Age: 47 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how a supplement called NAC (N-acetylcysteine) affects the brain and body in veterans who have Gulf War Illness — a condition that causes chronic fatigue, pain, and thinking problems in people who served in the 1990-1991 Gulf War. Researchers want to understand the biological mechanisms behind the illness and whether NAC might help. You may be eligible if: - You are between 47 and 70 years old - You served in the Gulf War Theater between August 1990 and July 1991 - You have been diagnosed with Gulf War Illness under the Kansas definition - You are willing to attend follow-up visits You may NOT be eligible if: - You have active major depression with psychotic features, schizophrenia, bipolar disorder, dementia, or drug/alcohol abuse - You have severe claustrophobia or difficulty with MRI scanning - You have active HIV, Hepatitis B, or Hepatitis C - You have significant kidney or liver disease - You have uncontrolled diabetes - You are pregnant - You are currently on dialysis or taking certain antiviral medications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGN-Acetyl Cysteine

900mg 2x daily

DRUGPlacebo

Matching placebo bid


Locations(7)

VA Palo Alto Health Care System War Related Illness and Injury Study Center

Palo Alto, California, United States

Nova Southeastern University

Fort Lauderdale, Florida, United States

Boston University Medical School

Boston, Massachusetts, United States

VA New Jersey Health Care System War Related Illness and Injury Study Center

East Orange, New Jersey, United States

Weill Cornell Medical College

New York, New York, United States

RTI International

Durham, North Carolina, United States

Michael E. DeBakey VA Medical Center

Houston, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT04987775


Related Trials