Comparing Hypo-fractionated Intensity- Modulated Radiation Therapy to Standard- Fractionated IMRT Along With Chemotherapy and Immunotherapy for Non-Small Cell Lung Cancer

This study compares two approaches to radiation therapy — a shorter, higher-dose schedule (hypofractionated IMRT) versus the traditional longer schedule (standard IMRT) — both given alongside chemotherapy and immunotherapy for patients with stage III non-small cell lung cancer that cannot be surgically removed. **You may be eligible if...** - You are 18 or older with confirmed stage IIIA or IIIB non-small cell lung cancer - Your cancer has not spread to other parts of the body (no metastases on PET/CT or brain MRI) - You are in reasonably good health (ECOG 0–2) - You have adequate organ function - Women of childbearing age must have a negative pregnancy test **You may NOT be eligible if...** - You have had prior chest (thoracic) radiation - You have HIV/AIDS - You have active autoimmune connective tissue disease (e.g., lupus, scleroderma) - You have a serious active infection - You are pregnant or breastfeeding - You are currently on other anti-cancer treatments Talk to your doctor to see if this trial is right for you.