Intra-Operative Radiation Registry

This registry study tracks outcomes for women with early-stage breast cancer who receive intraoperative radiation therapy (IORT) — a technique that delivers targeted radiation directly to the surgical site during a lumpectomy, rather than over many weeks after surgery. **You may be eligible if...** - You are a woman aged 45 or older - You have early-stage invasive breast cancer (cT1-2, no lymph node involvement, estrogen receptor positive, tumor ≤3.5 cm) OR low-grade DCIS detected by mammogram - You are having breast-conserving surgery (lumpectomy) and are planned to receive IORT - You had a recent mammogram within 6 months **You may NOT be eligible if...** - You have confirmed positive lymph nodes in the armpit - You have multiple cancer sites in the same breast that cannot be removed with one lumpectomy - You carry BRCA1 or BRCA2 gene mutations - You are receiving neoadjuvant (pre-surgery) chemotherapy - You are pregnant Talk to your doctor to see if this trial is right for you.