Exercise as a Preventive Agent to Combat Immobility in Patients With Ovarian or Endometrial Cancers Receiving Chemotherapy

This study tests whether a structured exercise program during chemotherapy can prevent or reduce physical decline (like muscle weakness and fatigue) in women with stage III or IV ovarian or endometrial (uterine) cancer who are receiving first-line chemotherapy after surgery. **You may be eligible if...** - You are 18 or older with newly diagnosed stage III or IV ovarian or endometrial cancer - You are receiving first-line carboplatin and paclitaxel chemotherapy after surgery - Your doctor has cleared you for moderate-to-vigorous exercise - You can read, write, and understand English - You are willing to have two blood draws during the study **You may NOT be eligible if...** - You have pre-existing musculoskeletal, neurological, or heart/lung conditions that would make exercise unsafe - You have uncontrolled illness or serious psychiatric conditions - You have previously received chemotherapy for cancer (e.g., taxanes for breast cancer) Talk to your doctor to see if this trial is right for you.