RecruitingNot ApplicableNCT04998357

Autologous Mitochondrial Transplant for Cerebral Ischemia

Study Title: Autologous Mitochondrial Transplant for Cerebral Ischemia

Sponsor

University of Washington

Enrollment

20 participants

Start Date

Apr 29, 2021

Study Type

INTERVENTIONAL

Conditions

Cerebral Ischemia

Summary

The investigators propose to infuse healthy autologous mitochondria into cerebral vessels supplying brain tissue experiencing ischemia in patients who undergo standard-of- care endovascular reperfusion therapy.

Eligibility

Min Age: 18 YearsMax Age: 85 Years

Inclusion Criteria3

Eligible for endovascular thrombectomy to treat acute large vessel occlusion
Eligible for angioplasty (microcatheter-based balloon/mechanical and chemical angioplasty) to treat acute cerebral vasospasm after aneurysmal subarachnoid hemorrhage
Subjects for whom there is likely to be enough time to obtain meaningful consent from patient or legally-authorized representative

Exclusion Criteria3

Unable to receive a brain MRI scan
Known mitochondrial disease
Hemodynamically unstable patients in whom standard of care endovascular reperfusion treatment cannot safely be performed or completed

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Interventions

OTHEREndovascular autologous mitochondrial transplantation

During standard-of-care endovascular reperfusion procedure, subjects will have autologous mitochondria infused via microcatheter into ischemic brain.

Locations(1)

Harborview Medical Center

Seattle, Washington, United States

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NCT04998357

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