Study on the Role of Human Serum Albumin in Large Acute Ischemic Stroke of Anterior Circulation After Thrombectomy

Exclusion Criteria19

• Intracranial hemorrhage confirmed by head CT or MRI.
• Pre-stroke mRS score \> 2.
• Severe allergy or absolute contraindication to iodine-based contrast agents.
• Systolic blood pressure \> 185 mmHg or diastolic blood pressure \> 110 mmHg, and inability to control with antihypertensive medication.
• Blood glucose \< 50 mg/dl (2.8 mmol/L) or \> 400 mg/dl (22.2 mmol/L) and difficult to correct.
• Genetic or acquired bleeding diathesis, deficiency of coagulation factors, or oral anticoagulation with INR \> 1.7.
• Severe renal dysfunction defined as serum creatinine \> 3.0 mg/dl (or 265.2 μmol/l) or glomerular filtration rate (GFR) \< 30 ml/min, or need for hemodialysis or peritoneal dialysis.
• Expected life expectancy \< 6 months.
• Anticipated inability of the patient to complete the 90-day follow-up.
• Suspected aortic dissection.
• Brain tumors, intracranial aneurysms, or arteriovenous malformations with mass effect on imaging.
• Neurological or psychiatric disorders affecting the assessment of the disease before the patient's stroke.
• Pregnancy or reproductive-age women with positive urinary or serum β-human chorionic gonadotropin (HCG) test.
• Currently participating in other clinical trials that may interfere with the results of this trial.
• History of allergy to albumin.
• Need for intermittent or long-term concomitant acute or chronic pulmonary diseases.
• Congestive heart failure for any reason in the past 6 months or any condition requiring medication, hospitalization, etc., related to heart failure.
• Symptomatic or diagnosed acute myocardial infarction, or occurrence of acute myocardial infarction within the past 6 months.
• Other situations that the investigator believes are not suitable for participation or may pose significant risks to the patient.