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RecruitingNot ApplicableNCT05010109

Cardiovascular Injury and Cardiac Fitness in Locally Advanced Non-Small Cell Lung Cancer Patients Receiving Model Based Personalized Chemoradiation

Longitudinal Assessment of Cardiovascular Injury and Cardiac Fitness in LA-NSCLC Patients Receiving Model Based Personalized Chemoradiation - an Adaptive Cohort Registration Study

Sponsor

M.D. Anderson Cancer Center

Enrollment

100 participants

Start Date

Jul 5, 2021

Study Type

INTERVENTIONAL

Conditions

Locally Advanced Lung Non-Small Cell CarcinomaStage III Lung Cancer AJCC v8Stage IIIA Lung Cancer AJCC v8Stage IIIB Lung Cancer AJCC v8Stage IIIC Lung Cancer AJCC v8

Summary

This study assesses cardiovascular injury and cardiac fitness in patients with non-small cell lung cancer that has spread to nearby tissue or lymph nodes (locally advanced) receiving model based personalized chemoradiation. The goal of this study is to learn more about the risk of developing heart disease as a result of chemoradiation treatment for lung cancer. Researchers also want to learn if the risk can be reduced by using a patient's individual risk profile to guide cancer treatment and help protect the heart.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tracks heart health and physical fitness over time in people with lung cancer who are receiving radiation therapy to the chest combined with chemotherapy and/or immunotherapy. The goal is to understand how this treatment affects the heart and fitness levels. **You may be eligible if...** - You are 18 or older with a diagnosis of non-small cell or small cell lung cancer - Your treatment plan includes radiation therapy to the chest along with chemotherapy and/or immunotherapy - Your general health is good enough (KPS ≥70) - You are willing to perform a 6-minute walk test and provide blood samples for heart biomarkers **You may NOT be eligible if...** - You have previously had radiation therapy to the chest in an area overlapping with your current treatment - You are pregnant - You are unable or unwilling to give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURE6 Minute Walk Functional Test

Participate in 6 MWT

PROCEDUREBiospecimen Collection

Undergo blood and urine sample collection

PROCEDUREComputed Tomography

Undergo SPECT/CT

PROCEDUREEchocardiography

Undergo echocardiogram

PROCEDUREExercise Cardiac Stress Test

Undergo stress test

OTHERQuestionnaire Administration

Complete questionnaires

PROCEDURESingle Photon Emission Computed Tomography

Undergo SPECT/CT

Locations(1)

M D Anderson Cancer Center

Houston, Texas, United States

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NCT05010109

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