RecruitingPhase 1Phase 2NCT05019690

Apatinib Combined with Albumin-Bound Paclitaxel for Treatment of Advanced Triple Negative Breast Cancer

Apatinib Mesylate Combined with Albumin-bound Paclitaxel for Second-line Treatment of Advanced Triple Negative Breast Cancer:a Single-arm,exploratory Clinical Study


Sponsor

Fujian Cancer Hospital

Enrollment

29 participants

Start Date

Oct 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a single-arm,exploratory clinical study, to evaluate the effectiveness and safety of apatinib mesylate combined with albumin-bound paclitaxel for second-line treatment of advanced triple negative breast cancer.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests a combination of apatinib (a targeted drug that cuts off blood supply to tumors) and albumin-bound paclitaxel (a form of chemotherapy) for women with advanced triple-negative breast cancer — a type that lacks hormone receptors and does not respond to many targeted therapies. **You may be eligible if...** - You are a woman between 18 and 75 years old - You have advanced triple-negative breast cancer confirmed by biopsy (HER2-negative, estrogen receptor-negative, progesterone receptor-negative) - You have measurable or evaluable disease on scans - Your overall health is adequate for chemotherapy **You may NOT be eligible if...** - You do not have triple-negative breast cancer - You have significant heart problems, uncontrolled high blood pressure, or severe bleeding risk - You are pregnant or breastfeeding - You have other serious medical conditions that make participation unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGApatinib Mesylate

Subjects receive Apatinib orally, Dosage form: tablet, Strength: 250 mg/tablet,QD,Q3W

DRUGAlbumin-Bound Paclitaxel

Subjects receive Albumin-Bound Paclitaxel,ivgtt, Strength: 125 mg/m\^2,d1、7、15,Q3W


Locations(1)

Fujian Cancer Hospital

Fuzhou, Fujian, China

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NCT05019690


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