Alteration of the Immune Microenvironment in Basal Cell Carcinoma Following Photodynamic Therapy

This study investigates how photodynamic therapy (using light and a photosensitizing drug to treat skin lesions) changes the immune environment within basal cell carcinoma (BCC), the most common form of skin cancer. Researchers will take small biopsies before and after treatment. **You may be eligible if...** - You are an adult scheduled to have Mohs surgery (a precise surgical technique) to remove basal cell carcinoma - You have at least one BCC tumor that can be removed by surgical excision - You are a man or woman of any ethnic background - You are willing and able to provide informed consent **You may NOT be eligible if...** - You are pregnant or breastfeeding - You are currently receiving treatment for other cancers with chemotherapy or radiation - You are allergic to aminolevulinic acid (ALA), the photosensitizing drug used - You have a history of a light-sensitive skin condition (such as porphyria) Talk to your doctor to see if this trial is right for you.