NEO100 and High-Grade Meningioma

This study tests NEO100 — a highly purified form of perillyl alcohol, a natural plant compound — as a treatment for high-grade meningioma (a type of brain tumor, WHO Grade II or III) that has come back or kept growing despite prior surgery and radiation. **You may be eligible if...** - You have been diagnosed with WHO Grade II or III meningioma confirmed by pathology - Your tumor is residual (remaining after surgery), progressive, or has recurred - You have already had surgery (at least a minimal safe resection) and radiation therapy - Your tumor is measurable on MRI (at least 10mm in both dimensions) - Your overall health is good enough to participate **You may NOT be eligible if...** - You have a Grade I (benign) meningioma - You have not yet received surgery and radiation - Your tumor is not measurable on imaging - You have significant other medical conditions that could interfere with the study - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.