RecruitingPhase 2NCT05028153

Azithromycin Treatment of Hospitalized Children With Asthmatic Symptoms

Azithromycin Treatment of Hospitalized Children With Asthmatic Symptoms: A Double-blinded, Randomized, Controlled Study


Sponsor

Copenhagen Studies on Asthma in Childhood

Enrollment

320 participants

Start Date

Nov 14, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this double-blind, randomized, controlled clinical trial is to investigate the effect of a three-day azithromycin treatment versus placebo treatment in children aged 1-5 years who are hospitalized due to asthma-like symptoms.


Eligibility

Min Age: 12 MonthsMax Age: 71 Months

Plain Language Summary

Simplified for easier understanding

This Danish study tests whether the antibiotic azithromycin can reduce the severity or length of asthma-like breathing episodes in young children aged 1 to 5 years who are hospitalized with wheezing. Azithromycin is thought to have anti-inflammatory properties beyond just fighting bacteria. **You may be eligible if...** - Your child is between 12 and 71 months old (1 to just under 6 years) - Your child has had at least one previous episode of asthma-like symptoms or wheezing and has been treated with inhaled medications - A parent or guardian speaks Danish fluently and agrees to participate **You may NOT be eligible if...** - Your child is allergic to macrolide antibiotics (like azithromycin or erythromycin) - Your child has liver or kidney problems - Your child has a neurological or psychiatric condition - Your child has a known heart rhythm problem (long QT syndrome) - Your child has signs of pneumonia (high fever, rapid breathing, elevated CRP) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAzithromycin Oral Liquid Product

10 mg/kg for 3 consecutive days

OTHERPlacebo mixture

Placebo mixture containing no active substance


Locations(1)

University Hospital of Copenhagen

Gentofte Municipality, Denmark

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NCT05028153