RecruitingNot ApplicableNCT05030207

Respiratory Adaptive Computed Tomography: Feasibility Study on Real-Time Gated 4DCT for Lung Cancer Radiotherapy

Respiratory Adaptive Computed Tomography: A Pilot Feasibility Study on the Use of Real-Time Gated 4DCT for Lung Cancer Radiation Therapy

Sponsor

University of Sydney

Enrollment

30 participants

Start Date

May 15, 2024

Study Type

INTERVENTIONAL

Conditions

Lung Cancer

Summary

This study does not involve a therapeutic intervention as standard radiation therapy treatment will be prescribed. This study involves one additional 4DCT scan (i.e. the Real-Time Gated 4DCT scan) acquired immediately before or following the conventional 4DCT scan. This will take place on the day of the patient's treatment simulation, as per the current standard of care. The scanning sequence (i.e. conventional first versus gated first) will be randomised. The Real-Time Gated 4DCT is anticipated to take longer than the conventional 4DCT scan, due to its gated (beam-pause) nature. However, upper limits for timing will be implemented in the software, and the scan aborted for highly erratic breathing traces that would not benefit from a Real-Time Gated 4DCT scan.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

years or older
Have the ability to give informed consent
A diagnosis of lung cancer with an indication for radiation therapy
Radiation therapy treatment involving the acquisition of a 4DCT scan for treatment planning

Exclusion Criteria3

Pregnant women
Patients \<18 years
Patients who in the opinion of the treating physician could not tolerate the extra time on the CT couch for an extra scan

Interventions

DIAGNOSTIC_TESTReal-time Gated 4DCT

Real-time gated four-dimensional cone beam computed tomography (4DCT) will be conducted at the simulation session. The Real-Time Gated 4DCT will be conducted while the patient moves through the rotating X-ray imager. This method detects and then pauses the CT beam during irregular breathing events.

DIAGNOSTIC_TESTConventional 4DCT

Four-dimensional computed tomography (4DCT), the standard of care for modern high-precision stereotactic ablative body radiotherapy (SABR), will be conducted at the simulation session. It will run continuously while the patient moves through the rotating X-ray imager.