RecruitingPhase 1NCT05030298

Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial

Preoperative Radiosurgery in High Grade Glioma: A Phase I Clinical Trial: The NeoGlioma Study


Sponsor

Mayo Clinic

Enrollment

28 participants

Start Date

May 23, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This phase I trial finds out the possible benefits and/or side effects of radiosurgery before surgery (preoperative) in treating patients with high grade glioma. Radiosurgery uses special equipment to position the patient and precisely give a single large dose of radiation to the tumor. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Giving pre-operative radiosurgery may improve the odds of brain tumor control and reduce treatment-related side effects.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Biopsy, a procedure called Biospecimen Collection, and others for people with malignant glioma. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONRadiation Therapy

Undergo radiation therapy

RADIATIONRadiosurgery

Undergo radiosurgery

PROCEDUREStereotactic Biopsy

Undergo MRI-guided stereotactic biopsy

DRUGTemozolomide

Drug

PROCEDURETumor Treating Fields Therapy

Undergo TTF

PROCEDUREMagnetic Resonance Imaging

Undergo MRI

PROCEDUREBiospecimen Collection

Undergo blood sample collection

PROCEDUREBiopsy

Undergo biopsy

PROCEDURETherapeutic Conventional Surgery

Undergo surgery


Locations(2)

Mayo Clinic in Arizona

Phoenix, Arizona, United States

Mayo Clinic in Florida

Jacksonville, Florida, United States

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NCT05030298


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