CARv3-TEAM-E T Cells in Glioblastoma

This study tests a new type of engineered immune cell therapy for people with glioblastoma (a serious brain tumor). The therapy uses modified T cells designed to attack brain tumor cells carrying a specific mutation called EGFRvIII, with the goal of killing more cancer cells than standard treatments can. **You may be eligible if...** - You have been diagnosed with glioblastoma (GBM) — either newly diagnosed or returning after prior treatment - Your tumor carries the EGFRvIII mutation (for Arms 1 and 2) or has EGFR amplification without EGFRvIII (Arm 3) - You are planning to have a biopsy or surgery to remove tumor tissue - You have already received radiation therapy (for recurrent disease arms) - You are in good enough health to undergo the procedure **You may NOT be eligible if...** - Your tumor does not have the required genetic features - You have not yet received prior radiation (for the recurrent arms) - You have had recent chemotherapy or immunotherapy without the required washout period - You do not meet other health or safety requirements set by the study team Talk to your doctor to see if this trial is right for you.