The Impact of Focused Ultrasound Thalamotomy of the Anterior Nucleus for Focal-Onset Epilepsy on Anxiety

This trial studies whether focused ultrasound — a non-invasive brain treatment that uses sound waves to precisely target a brain region called the anterior nucleus of the thalamus — can reduce anxiety in people with drug-resistant epilepsy. Patients already qualify for this procedure for seizure control; this study adds assessments of anxiety before and after. **You may be eligible if...** - You have epilepsy that has not responded to at least 2 anti-seizure medications - You have at least 3 seizures per month on average - Your seizures start in a specific brain area (focal onset) and may spread - You have moderate-to-severe anxiety (HAM-A score above 17) - Your medications have been stable for at least 3 months - You have had a recent comprehensive epilepsy workup including EEG and MRI **You may NOT be eligible if...** - You have fewer than 3 seizures per month - You have purely generalized epilepsy (such as Lennox-Gastaut syndrome) - Your target brain area cannot be identified on MRI - You have other serious medical or psychiatric conditions that interfere with participation Talk to your doctor to see if this trial is right for you.