RecruitingNCT05039788

Observational Single-center Study of the Relationship Between Arterial Hypertension and Hypervolemia Defined by Self-measurement of Impedancemetry in Kidney Transplant Patients With Transplantation Less Than 6 Months Old

Monocentric Observational Study to Determine the Relationship Between Arterial Hypertension and Hypervolaemia, Defined by Self-measurement of Impedancemetry in Kidney Transplant Recipients Under 6 Months Old


Sponsor

Nantes University Hospital

Enrollment

150 participants

Start Date

Oct 14, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

The working hypothesis is that hypertension during the first post-transplant trimester is partly explained by the patient's hypervolemia. The main objective of the single-center observational study "HTA ô Connect" is to study the relationship between hypertension and extracellular hyperhydration, thanks to repeated self-measurements of blood pressure and impedancemetry between the 30th and the 90th day post-transplant, in 150 incident kidney transplant patients from our department, the ITUN (Institute of Urology-Nephrology Transplantation). The study population involves 150 incident kidney transplant patients, presenting to the Nantes University Hospital Transplant Institute for 1 month (D30), and presenting with hypertension ≥ 140/90mmHg and not treated with a diuretic. Data collected at the patients' homes will be used to establish a relationship between blood pressure and extracellular water volume. The data collected will not be used to follow up patients who participated in the study in this first stage of exploration.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This observational study is looking at whether excess fluid in the body (fluid overload) is linked to high blood pressure in people who recently had a kidney transplant. Participants will have their body fluid measured using a simple bioelectrical impedance device. **You may be eligible if...** - You are 18 or older - You received a kidney transplant less than 6 months ago - You have high blood pressure (at least 140/90 mmHg on 3 occasions) - Your BMI is between 16 and 34 kg/m² - You are willing to participate **You may NOT be eligible if...** - You have had a transplant of an organ other than the kidney - You are currently taking diuretic (water) pills - You are a minor or are under legal protection Talk to your doctor to see if this trial is right for you.

This is a simplified summary. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERMeasurement of systolic and diastolic blood pressure, impedancemetry, weight, creatinemia and Pro-BNP measurements

Measurement of systolic and diastolic blood pressure, impedancemetry, weight, creatinemia and Pro-BNP measurements At D30 and D90 Measurement of systolic and diastolic blood pressure, impedancemetry, weight, 3 times a week between D30 and D90 post-transplant,


Locations(1)

Nantes University Hospital

Nantes, Loire-Atlantique, France

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NCT05039788