R-CDOP Regimen in the Treatment of Newly Diagnosed Non-Hodgkin's Lymphoma With High Tumor Burden

This trial is testing a modified chemotherapy regimen called R-CDOP — which replaces one standard drug with a liposomal formulation to potentially reduce heart-related side effects — in patients with newly diagnosed diffuse large B-cell lymphoma or grade 3B follicular lymphoma with a large tumor burden. **You may be eligible if...** - You are between 18 and 75 years old with a confirmed diagnosis of diffuse large B-cell or grade 3B follicular lymphoma - Your lymphoma has high tumor burden (e.g., large tumors, multiple sites, high LDH, fluid buildup) - You have never been treated for this lymphoma before - Your performance status is ECOG 0–2 and organ function is adequate **You may NOT be eligible if...** - You have received prior treatment for this lymphoma - You have significant heart disease (heart failure, prior heart attack, severe valve disease) - You have active infections (including HIV, hepatitis B, C) - You are pregnant or breastfeeding - You have previously had severe allergic reactions to any of the study drugs Talk to your doctor to see if this trial is right for you.