RecruitingPhase 2Phase 3NCT05047133

Effect of Early Administration of TXA in Adult Hip Fractures

Does Early Administration of Tranexamic Acid Decrease Perioperative Blood Loss in Addition to Intraoperative Tranexamic Acid for Hip Fracture Patients?

Sponsor

Ascension Health

Enrollment

170 participants

Start Date

Sep 1, 2021

Study Type

INTERVENTIONAL

Conditions

Postoperative Blood Loss

Summary

This is a prospective clinical study designed to assess blood loss in intracapsular and extracapsular hip fractures undergoing operative fixation at a Level II trauma center. It is well established in the orthopedic literature that tranexamic acid (TXA) decreases blood loss and need for postoperative blood transfusion in hip fracture patients as well as total joint arthroplasty patients. A typical dosing pattern, and the dosing pattern employed at our institution, is 1 gram IV infused prior to incision followed by 1 gram IV infused at the time of wound closure.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether giving the blood-clot-preventing drug tranexamic acid (TXA) early — before surgery — reduces blood loss and the need for blood transfusions in adults who have broken their hip and need an operation to fix it. You may be eligible if: - You are 18 years of age or older - You have an acute hip fracture - You are going to have surgery to repair the fracture You may NOT be eligible if: - You have multiple major traumatic injuries (polytrauma) - You have had previous surgery on the same hip - You have a blood clotting disorder (e.g., Factor V Leiden, Sickle Cell Anemia) - You have had a blood clot, stroke, cardiac stent, or heart attack in the past 6 months - You have a history of seizure disorder - You are on birth control pills - You are pregnant - You are currently incarcerated Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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