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RecruitingNCT05049538

Determine the Utility of Liquid Biopsies and Tumor Molecular Profiling in Predicting Recurrence in Endometrial Cancers

A Pilot Investigation to Determine the Utility of Liquid Biopsies and Tumor Molecular Profiling in Predicting Recurrence in Endometrial Cancer

Sponsor

M.D. Anderson Cancer Center

Enrollment

1,000 participants

Start Date

Jun 18, 2019

Study Type

OBSERVATIONAL

Conditions

Malignant Uterine NeoplasmEndometrial Clear Cell AdenocarcinomaEndometrial Dedifferentiated CarcinomaEndometrial Mucinous AdenocarcinomaEndometrial Serous AdenocarcinomaUterine Corpus Carcinosarcoma

Summary

This study is to find out how well liquid biopsies work as a non-invasive alternative to other methods of finding cancer cells (such as a tissue biopsy) in patients with endometrial cancer. A liquid biopsy is a blood test that may be able to find cancer cells. Collecting and storing samples of blood and tissue from patients with endometrial cancer to study in the laboratory may help doctors learn how the cells in the blood may change during treatment for uterine cancer.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses liquid biopsies (a blood test that detects cancer DNA) and detailed molecular profiling of tumors to better predict which endometrial cancer patients are at risk of their cancer coming back after surgery. The goal is to identify women who may benefit from additional treatment monitoring. **You may be eligible if...** - You are a woman 18 or older with a confirmed diagnosis of endometrial (uterine) cancer - You are scheduled for surgery or have recently had surgery as primary treatment - You have not yet received chemotherapy or radiation for this cancer **You may NOT be eligible if...** - You have already received chemotherapy or radiation for endometrial cancer - You cannot give informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREBiospecimen Collection

Undergo collection of blood and tissue samples

PROCEDURELiquid Biopsy

Undergo liquid biopsy

OTHERPap Smear

Undergo Pap smear

Locations(1)

M D Anderson Cancer Center

Houston, Texas, United States

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NCT05049538

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