Wide Excision of Soft Tissue Sarcomas in Combination With Interstitial Radiation Therapy

This study tests whether combining surgery (wide excision) with internal radiation therapy (interstitial brachytherapy — where radiation seeds are placed directly inside or near the tumor site) can effectively treat soft tissue sarcomas of the arms and legs while preserving the limb. **You may be eligible if...** - You have a soft tissue sarcoma in your arm (including shoulder) or leg (including hip), grade 2 or 3 - Your tumor is 7 cm or smaller - You have locally advanced or recurrent sarcoma with no spread to lymph nodes - You are 18 or older **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have certain specific sarcoma subtypes (e.g., Kaposi's sarcoma, chondrosarcoma, GIST) - Your tumor cannot be surgically removed or is breaking down (decaying) - You have skin damage in the affected area - You have another active cancer - You have an active chronic infection Talk to your doctor to see if this trial is right for you.