Minipuberty in Infants Born With Potential Hypogonadism Hypogonadotrope
Evaluation of Minipuberty in Infants Born With a Variation in Sexual Development
Centre Hospitalier Universitaire Vaudois
100 participants
Jan 1, 2017
OBSERVATIONAL
Conditions
Summary
Disorders of sex development (DSD) occur in 1/3000 births and are defined by variation in aspect of external genital organs, e.g. cryptorchidism, hypospadias and micropenis in male infants and clitoral hypertrophy in female infants. Genetic, hormonal and environmental factors are implicated in DSD. Infants with congenital hypogonadism hypogonadotrope (CHH) can present with DSD. Evaluation of hormonal profile during minipuberty could be of great help to better characterize the etiology of DSD and CHH in particular. Our main objective is to study hormonal profile during the minipuberty of infants born with DSD or born from parents with CHH compared to controls.
Eligibility
Inclusion Criteria2
- infants born with symptoms of DSD
- infants born from parents with CHH
Exclusion Criteria2
- premature < 35 weeks of gestation
- male infants with high scrotal cryptorchidism
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Locations(1)
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NCT05058781