Amyloid-β Clearance Mechanisms in Alzheimer's Disease

This study investigates how the brain clears amyloid-beta — a protein that builds up in Alzheimer's disease — by looking at the flow of cerebrospinal fluid (the fluid around the brain and spinal cord). Researchers want to understand if improving this clearance process could slow Alzheimer's progression. **You may be eligible if...** - You have mild cognitive impairment (MCI), early Alzheimer's dementia, or are cognitively normal (as a comparison group) - You are fluent in German - Your medications have been stable for at least 4 days before your study visit **You may NOT be eligible if...** - You have schizophrenia, bipolar disorder, or severe depression - You have active suicidal thoughts - You currently abuse alcohol, drugs, or medications - You have had a serious head injury in the last 3 months - You have epilepsy, severe heart failure, uncontrolled high blood pressure, or other serious neurological conditions - You cannot have an MRI (e.g., pacemaker or other metal implants) - You are pregnant or have kidney failure Talk to your doctor to see if this trial is right for you.