RecruitingNCT05063955

Mechanism of Sarcopenia in Heart Failure

Socioeconomic Factors and Mechanisms of Sarcopenia and Muscle Strength in Chronic Heart Failure Patients

Sponsor

Aarhus University Hospital

Enrollment

250 participants

Start Date

Dec 2, 2020

Study Type

OBSERVATIONAL

Conditions

Heart Failure Sarcopenia Cachexia

Summary

The aim of the study is to provide information on the interaction between socioeconomic factors, daily physical activity, nutrition and lifestyle on loss of muscle mass and muscle function in patients with heart failure.

Eligibility

Min Age: 18 YearsMax Age: 90 Years

Inclusion Criteria2

Ability to provide valid informed consent.
Heart failure with preserved, mid-range or reduced ejection fraction (NYHA I-IV) according to European Society of Cardiology guidelines.

Exclusion Criteria4

Cancer requiring treatment (e.g. prostate cancer on watchful waiting does not exclude patients).
Severe musculoskeletal or neurological disability.
Severe lung disease with a forced expiratory volume 1 \< 40% of predicted. Treatment with anticoagulants (warfarin, apixaban, edoxaban, dabigatran and rivaroxaban) is an exclusion criterion for muscle biopsy. Patients with anticoagulant treatment will be invited to participate in the study without muscle biopsy.
Other comorbidities that prevent the patient from participating in the study examinations as judged by the investigator.