Psilocybin-facilitated Treatment for Chronic Pain

This study investigates whether psilocybin (a compound found in psychedelic mushrooms) can help reduce widespread chronic pain in women with fibromyalgia — a condition characterized by widespread musculoskeletal pain, fatigue, and sleep problems that is often difficult to treat with standard medications. You may be eligible if: - You are a woman between 25 and 65 years old - You have had widespread musculoskeletal pain for at least 12 months - You meet the diagnostic criteria for fibromyalgia - Your average daily pain is at least 5 out of 10 - You have not used hallucinogens in the past 3 years (or have never used them) - You have a trusted person who can drive you home after drug sessions - You can attend all visits at the study location You may NOT be eligible if: - You are male - You have used opioid medications in the last 60 days - You are taking antidepressants (SSRIs, MAOIs, tricyclics), antipsychotics, lithium, or St. John's Wort - You have a personal or family history of psychotic disorders or bipolar disorder - You have uncontrolled high blood pressure, active infections, or autoimmune conditions - You are pregnant or planning to become pregnant within 6 months Talk to your doctor to see if this trial is right for you.