RecruitingEarly Phase 1NCT05069220

18F-MFBG PET/CT in the Evaluation of Neural Crest Tumor

A Study of 18F-MFBG Imaging for the Tumor Burden Evaluation or Diagnostic Performance in Pheochromocytoma, Paraganglioma and Neuroblastoma.


Sponsor

Peking Union Medical College Hospital

Enrollment

150 participants

Start Date

Sep 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

The aim of this study is to evaluate the diagnostic performance and tumor burden of 18F-metafluorobenzylguanidine (18F-MFBG) positron emission tomography (PET) in patients with neuroendocrine tumors mainly in pheochromocytoma and paraganglioma (PPGL) and neuroblastoma (NB).


Eligibility

Min Age: 1 YearMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study evaluates a new imaging drug called 18F-MFBG, used in PET/CT scans, to detect neural crest tumors — a group of cancers including neuroblastoma (common in children), pheochromocytoma, and paraganglioma. It compares this new scan to the standard MIBG scan currently used. **You may be eligible if...** - You have a confirmed or suspected neural crest tumor (e.g., neuroblastoma, pheochromocytoma, or paraganglioma) - If you have neuroblastoma, you have had or are scheduled for a standard MIBG scan within 6 months - You are not pregnant or breastfeeding **You may NOT be eligible if...** - You are pregnant, breastfeeding, or may become pregnant - You had surgery between the time of selection and enrollment - Your doctor determines you are not suitable for this study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUG18F-MFBG

Patients with neuroendocrine malignancies receive 2-4 MBq/kg of 18F-MFBG intravenously followed by PET/CT after 60min of injection.

DRUG68Ga-Dotatate

Patients with malignant PPGL and NB receive intravenously 68Ga-Dotatate followed by PET/CT after 40min of injection.


Locations(1)

Peking union medical college hospital

Beijing, Dongcheng, China

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NCT05069220


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