RecruitingNot ApplicableNCT05071131

Effect of Inulin on Gut Microbiota and Gut Barrier in Chronic Kidney Disease

Investigating the Effect of Inulin on Gut Microbiota and Gut Barrier in Advanced Chronic Kidney Disease - a Randomised, Placebo-controlled Trial


Sponsor

Charite University, Berlin, Germany

Enrollment

40 participants

Start Date

Feb 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

An adequate fiber intake is crucial for a well-balanced diet and reduces the risk of chronic diseases. However, nutritional recommendations for chronic kidney disease patients lead to an insufficient fiber intake with possible maladaptive effects on the gut microbiome. Therefore, we want to study the effects of a 35-day inulin supplementation on the gut microbiome, gut barrier function, bacterial metabolites and immune cell states in chronic kidney disease patients.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at whether a fiber supplement called inulin can improve gut bacteria and strengthen the gut barrier in people with end-stage kidney disease on dialysis. **You may be eligible if...** - You are 18–75 years old - You have end-stage kidney disease and have been receiving hemodialysis regularly for at least 3 months - Your BMI is between 18.5 and 39.9 kg/m² **You may NOT be eligible if...** - You have cancer - You are currently hospitalized or recently had surgery - You have an active infection - You have taken antibiotics in the last 4 weeks - You currently take probiotic or prebiotic supplements - You have had significant weight loss (more than 2 kg) in the past month - You have a history of drug or alcohol abuse Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTInulin

1 sachet à 15 grams daily for 7 days, followed by 2 sachets à 15 grams daily for 28 days

DIETARY_SUPPLEMENTPlacebo

1 sachet à 15 grams daily for 7 days, followed by 2 sachets à 15 grams daily for 28 days


Locations(1)

Experimental and Clinical Research Center

Berlin, Germany

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NCT05071131


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