RecruitingPhase 2NCT05071937

ZEN003694 Combined With Talazoparib in Patients With Recurrent Ovarian Cancer

Phase ll Study of a BET Inhibitor, ZEN003694, Combined With a PARP Inhibitor, Talazoparib, in Patients With Recurrent Ovarian Cancer


Sponsor

Alexander B Olawaiye, MD

Enrollment

33 participants

Start Date

Apr 21, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

This Phase 2, open label, study with safety lead in of oral talazoparib in combination with ZEN003694 given daily in 28-day cycles will enroll patients with recurrent ovarian, fallopian tube or primary peritoneal carcinoma.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is testing a combination of two drugs — ZEN003694 (a BET inhibitor) and talazoparib (a PARP inhibitor) — in women with ovarian cancer that has come back after prior treatment. **You may be eligible if...** - You are a woman aged 18 or older with ovarian, fallopian tube, or peritoneal cancer that has returned - You have previously been treated with a PARP inhibitor - You have at least one measurable tumor - You know your BRCA1/2 gene status - Your blood counts and organ function are within acceptable ranges - You are post-menopausal or using highly effective contraception **You may NOT be eligible if...** - You have severe liver or kidney impairment - You are pregnant or breastfeeding - You have an active serious infection or autoimmune condition - You have recently had a blood transfusion (within 4 weeks) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGZEN003694

ZEN003694 has shown promising activity in the treatment of solid tumors and hematologic (blood) cancers by reducing the multiplication of cancer cells.

DRUGTalazoparib

Talazoparib kills cancer cells by inhibiting and trapping the enzyme PARP, which is known to be involved in the development of many types of cancers.


Locations(1)

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05071937


Related Trials