DSAEK/DMEK and Cystoid Macular Edema - the Role for Topical NSAIDs (Nepafenac) (DMEC)

This study investigates whether a topical eye drop medication called nepafenac (an anti-inflammatory NSAID) can prevent cystoid macular edema (CME) — a type of swelling in the center of the retina — after corneal transplant surgery (DSAEK or DMEK). CME can impair vision after what is otherwise a successful transplant. You may be eligible if: - You are 18 years or older - You are scheduled to undergo DSAEK or DMEK corneal transplant surgery - You are able to cooperate during eye examinations - You are willing and able to participate and provide informed consent You may NOT be eligible if: - You have a known contraindication to any study medication (e.g., allergy, pregnancy, breastfeeding) - You already have macular edema before surgery - This is a repeat (re-transplantation) procedure - You have an implanted glaucoma shunt or valve in the eye - You do not have a lens in your eye (aphakic) - Your expected vision after surgery is very poor (below 0.1 Snellen) Talk to your doctor to see if this trial is right for you.