RecruitingPhase 4NCT05072262

DSAEK/DMEK and Cystoid Macular Edema - the Role for Topical NSAIDs (Nepafenac) (DMEC)

A Randomized Clinical Two-arm Trial Comparing Inflammation and Cystoid Macular Edema for the Medication Regimens Postoperative Topical NSAIDs and Steroids to Only Postoperative Topical Steroids in Patients Undergoing Corneal Endothelial Transplantations (DMEC)

Sponsor

Oslo University Hospital

Enrollment

300 participants

Start Date

Nov 25, 2022

Study Type

INTERVENTIONAL

Conditions

Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)Descemet Membrane Endothelial Keratoplasty (DMEK)

Summary

The DMEC trial is a randomized clinical two-arm trial comparing inflammation and cystoid macular edema for the medication regimens postoperative topical NSAIDs and steroids to only postoperative topical steroids in patients undergoing corneal endothelial transplantations (DSAEK or DMEK).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Dexamethasone Ophthalmic and a drug called Nepafenac Ophthalmic for people with descemet membrane endothelial keratoplasty (dmek) and descemet stripping automated endothelial keratoplasty (dsaek). The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNepafenac Ophthalmic

Topical nepafenac (Nevanac) 3 mg/ml

DRUGDexamethasone Ophthalmic

Topical dexamethasone 1 mg/ml (Spersadex)

Locations(1)

Department of Ophthalmology, Oslo University Hospital

Oslo, Norway

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NCT05072262

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