Reverse Triple Negative Immune Resistant Breast Cancer

This trial is studying treatment options for triple-negative breast cancer (a type with no estrogen, progesterone, or HER2 receptors) that has stopped responding to immunotherapy, aiming to reverse immune resistance. **You may be eligible if...** - You have metastatic or locally advanced triple-negative breast cancer (TNBC) - Your cancer progressed during or after immunotherapy (combined with targeted therapy or chemotherapy) - You have at least one measurable tumor - Your general health is adequate (ECOG 0–2) - You are able to understand the study and commit to follow-up **You may NOT be eligible if...** - You have active brain metastases causing symptoms - You have an active autoimmune disease or immune deficiency - You have significant heart disease - You had another cancer within the past 5 years - You are pregnant or breastfeeding - You received cancer treatment within 3 weeks of joining Talk to your doctor to see if this trial is right for you.