Preoperative mFOLFIRINOX (or Gem-Nab-P) +/- Isotoxic High-dose SBRT for Borderline Resectable Pancreatic Adenocarcinoma

This study is testing whether adding a focused radiation treatment (called SBRT) to standard chemotherapy before surgery can improve outcomes for people with borderline resectable pancreatic cancer — cancer that sits near important blood vessels and may or may not be removable by surgery. **You may be eligible if...** - You have been diagnosed with pancreatic cancer (adenocarcinoma) and scans show it is "borderline resectable" — meaning surgery might be possible - You are 18 or older - You have not had any prior chemotherapy or radiation for pancreatic cancer - You are in reasonably good physical health (able to carry out daily activities) - Your blood counts, liver, and kidney function are within acceptable ranges **You may NOT be eligible if...** - The cancer has spread beyond the pancreas to distant sites or lymph nodes - The cancer is too locally advanced (wrapping around major arteries) - You have had previous radiation to the upper abdomen - You have a serious uncontrolled medical condition - You are pregnant or breastfeeding - You are under 18 Talk to your doctor to see if this trial is right for you.