ROSE-Longitudinal Assessment With Neuroimaging
Recovery and Outcomes From Stroke-Longitudinal Assessment With Neuroimaging
State University of New York at Buffalo
250 participants
Sep 30, 2020
OBSERVATIONAL
Conditions
Summary
The investigators will perform follow-up on 250 of 500 cases recruited into the ROSE study of cases with deep and lobar intracerebral hemorrhage to perform advanced neuroimaging at 12-24 months post stroke, and evaluations of motor and cognitive function at baseline, 6 months after baseline, and 12 months after baseline to determine predictors of recovery, progressive cognitive or functional impairment. The investigators propose to leverage the recruitment, DNA, RNA-seq and baseline advanced neuroimaging cohort of ROSE to obtain long-term neuroimaging and identical assessments longitudinally to address critical questions regarding the progressive decline of patients 12 to 24 months post intracerebral hemorrhage (ICH) with long term cognitive follow-up to 36 months on average. This proposal would represent the largest, and longest advanced neuroimaging and RNA-sequencing evaluation after ICH to date.
Eligibility
Inclusion Criteria3
- Age 18 years or greater, fulfillment of the criteria for Deep, Subcortical or Lobar Intracerebral Hemorrhage
- No evidence of trauma, vascular malformation or aneurysm, or brain tumor as a cause of ICH.
- Ability of the patient or legal representative to provide informed consent
Exclusion Criteria2
- Brainstem or Cerebellar ICH
- Patients Severely Affected by the ICH, Early Mortality, Hospice, or Withdraw of Care NOT eligible for ROS
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Locations(7)
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NCT05089331