RecruitingNot ApplicableNCT05090865

Dietary Potassium Liberalization in Pre-Dialysis Patients

Dietary Potassium Liberalization With Fruit and Vegetables Versus Potassium Restriction in People With Chronic Kidney Disease (DK-Lib CKD) Trial

Sponsor

University of Manitoba

Enrollment

30 participants

Start Date

Jan 15, 2024

Study Type

INTERVENTIONAL

Conditions

Chronic Kidney Disease Hyperkalemia

Summary

The study will look at the impact of the potassium content in fruits and vegetables, on serum potassium concentrations in people with Chronic Kidney Disease (CKD) using a randomized crossover design. Participants will receive home delivery of fruit and vegetables with either higher or lower potassium content in a random order. Clinical chemistry markers from blood and urine samples, blood pressure, physical functioning and health related quality of life will be assessed throughout the duration of the trial. This study will also measure their physical functioning, using a chair stand test. The results of this study could change the dietary recommendations for people with CKD related to potassium.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether people with chronic kidney disease (CKD) who are not yet on dialysis can safely eat more potassium-rich foods (such as fruits and vegetables) without their blood potassium levels becoming dangerously high. Many CKD patients are told to restrict potassium, but this may be overly cautious for some. **You may be eligible if...** - You are 18 or older - You have chronic kidney disease with a filtration rate between 15 and 45 (moderate-to-severe CKD, not yet on dialysis) - Your blood potassium level is between 4.5 and 5.5 mEq/L - Your blood sugar control is reasonable (HbA1c ≤ 11%) - Your blood pressure is below 160/100 mmHg - You are registered with a multidisciplinary kidney care clinic in Winnipeg - You can communicate in English **You may NOT be eligible if...** - Your potassium is already dangerously high (above 5.6 mEq/L) - You are on dialysis or have had acute kidney failure in the past 6 months - You have advanced heart failure (Class 3–4 symptoms) or have had a heart attack or stroke in the last 6 months - You are currently on potassium-binding medication - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTLiberalized dietary potassium via fruits and vegetables

On the liberalized dietary potassium intervention, participants will receive groceries delivered to their houses that contain potassium rich fruit and vegetables, that contain more than 250 mg of potassium per typical serving. Participants will be instructed to incorporate the fruit and vegetables into their diet targeting a daily intake of 2000 mg of potassium a day from delivered fruit and vegetables, and a daily dietary potassium intake of 3500 mg.

DIETARY_SUPPLEMENTStandard dietary potassium restriction

Participants will receive weekly supplementation of lower potassium fruit and vegetables, that deliver less than 200 mg of potassium per typical serving. Participants will be instructed to incorporate the fruit and vegetables into their diet targeting a daily intake of 500 mg of K a day from the box, and a daily dietary K intake \< 2000 mg. Participants will receive counselling from a registered dietician (RD) to reinforce the potassium restriction.