RecruitingPhase 1NCT05096715

Atezolizumab+Bevacizumab+SBRT in Unresectable HCC

Phase IB Study of Atezolizumab and Bevacizumab With SBRT for Unresectable Hepatocellular Carcinoma


Sponsor

Massachusetts General Hospital

Enrollment

20 participants

Start Date

Aug 23, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This research study is evaluating the safety and tolerability of the drugs atezolizumab and bevacizumab with stereotactic body radiation therapy (SBRT) for treating unresectable hepatocellular carcinoma. This study involves the following interventions: * Atezolizumab * Bevacizumab * Stereotactic body radiation therapy (SBRT)


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of atezolizumab (immunotherapy), bevacizumab (a drug that blocks tumor blood vessel growth), and targeted radiation (SBRT) for people with liver cancer (hepatocellular carcinoma) that cannot be removed by surgery and has not yet been treated with systemic therapy. **You may be eligible if...** - You have been diagnosed with hepatocellular carcinoma (liver cancer) confirmed by biopsy or imaging - Your cancer is deemed not suitable for surgery, transplant, or ablation - You have up to 5 tumor lesions, with no single lesion larger than 15 cm and total size under 20 cm - Your liver function is adequate (Child-Pugh A or B7) - You have not previously received systemic drug treatment for this cancer **You may NOT be eligible if...** - You have received prior immunotherapy or anti-VEGF treatment - You have active autoimmune disease - You are pregnant or breastfeeding - You have significant bleeding risk (e.g., esophageal varices) - Your liver disease is too advanced (Child-Pugh C) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGAtezolizumab

Intravenous Infusion

DRUGBevacizumab

Intravenous Infusion

RADIATIONStereotactic body radiation therapy (SBRT)

External Beam Radiation


Locations(3)

Massachusetts General Hospital Cancer Center

Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center

Boston, Massachusetts, United States

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05096715


Related Trials