Preventive Effect of Clopidogrel on the Systemic Sclerosis Development Risk
Phase II/III Double-blind Randomized Placebo-controlled Trial Assessing the Preventive Effect of Clopidogrel on the Systemic Sclerosis Development Risk in Subjects With Specific Dysimmunity and Raynaud Phenomenon
University Hospital, Bordeaux
90 participants
Jun 22, 2022
INTERVENTIONAL
Conditions
Summary
Systemic sclerosis (SSc) is a severe autoimmune disease associating dysimmunity, vasculopathy and fibrosis. No curative treatment is available. Pre-clinical abnormalities can be found such as specific autoantibodies. The association of Raynaud phenomenon and SSc-specific anti-nuclear antibodies is the hallmark of pre-scleroderma subjects, among who around 47% declare a complete disease after five years. The aim of this study is to assess in this particular population the preventive effect of an anti-platelet treatment.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
75 mg daily during 24 months
75 mg daily during 24 months
Locations(11)
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NCT05098704