RecruitingNot ApplicableNCT05099432

The CARMA Technique Study

The Cap-Assisted Resection Margin Assessment (CARMA) Technique After Polyp Resection: a Prospective Feasibility Study of a "Novel" Approach to Reduce Polyp Recurrence


Sponsor

Princess Alexandra Hospital, Brisbane, Australia

Enrollment

60 participants

Start Date

Nov 1, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

Colonoscopic removal of polyps is an important and well-established tool in the prevention of colorectal cancers. However, high polyp recurrence rates after endoscopic resection, with resultant development of interval cancers, remains a problem; this most commonly stems from unrecognised incomplete polyp resection. Thus, a standardised endoscopic technique is needed that will allow endoscopists to consistently achieve a clear margin of resection. The investigators believe the Cap Assisted Resection Margin Assessment (CARMA) technique will address this problem. This novel technique focuses on a standardised assessment of the resection margin after endoscopic polypectomy utilising available standard high-definition video endoscopes with imaging features including narrow band imaging (NBI) and magnification endoscopy.


Eligibility

Min Age: 16 Years

Inclusion Criteria2

  • Patients with colonic polyps will be considered following below criteria
  • \- any polypectomy (though only a maximum of two polyps from one individual participant)

Exclusion Criteria6

  • polyps less than 10mm which were resected under endoscopic view with a definite > 1mm clear margin
  • scar site recurrence polyps
  • polyps with endoscopic evidence of invasion
  • pedunculated polyps
  • pseudopolyps
  • participants who will not be available for follow up endoscopy

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Interventions

PROCEDURECARMA technique

Once standard polyp resection and assessment of the polypectomy site without magnification is completed, the CARMA technique will be applied. This will involve an assessment of the entire polypectomy margin using cap assisted magnification endoscopy with the ability to also use NBI (at the endoscopist's discretion) and documentation of any residual polyp noted.


Locations(1)

Princess Alexandra Hospital

Woolloongabba, Queensland, Australia

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NCT05099432


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