Imaging Measures of Respiratory Health Registry
University of British Columbia
1,000 participants
Jun 11, 2020
OBSERVATIONAL
Conditions
Summary
This is a prospective, observational cohort registry that aims to collect data on pulmonary structure and function in healthy people and those with respiratory disease, using structural and functional pulmonary 1H-MRI and hyperpolarized 129Xe-MRI. Outcome measures generated from MRI may include but are not limited to measures of regional ventilation, pulmonary microarchitecture, and regional gas exchange. Additionally, one of the goals of the registry is to facilitate the development of novel image analysis techniques that have not yet been invented. These data will be stored along with demographic data, clinical data, and pulmonary function testing (PFT) data. This is an open registry. Eligible local and international investigators/institutions can apply for access.
Eligibility
Inclusion Criteria8
- Respiratory Disease
- Physician-diagnosed lung disease - based on a diagnosis made by a treating staff physician and confirmed by the principal investigator.
- Age 0-99 years.
- Informed consent by participant, parent, or legal guardian
- In the opinion of the Investigator, the participant will likely be able to perform maneuvers to obtain technically acceptable pulmonary XeMRI images.
- Age 0-99 years
- Informed consent by participant, parent, or legal guardian
- In the opinion of the Investigator, the participant will likely be able to perform maneuvers to obtain technically acceptable pulmonary MRI images.
Exclusion Criteria11
- Physical findings at screening that, in the opinion of the Investigator, would compromise the safety of the participant or the quality of the research data.
- Requirement of supplementary oxygen to maintain an oxygen saturation above 95%.
- Failed MRI screening form.
- History of claustrophobia.
- Known current pregnancy or lactation.
- Healthy
- Physician-diagnosed lung disease.
- Failed MRI screening form.
- History of claustrophobia.
- Physical findings at screening that, in the opinion of the Investigator, would compromise the safety of the participant or the quality of the research data.
- Known current pregnancy or lactation.
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Interventions
Traditional 1H-MRI (room air inhalation) and Xe-129 MRI (requires inhalation of Xenon 129 gas).
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT05102825