RecruitingPhase 2NCT05104788

A Study of Icotinib With Chemotherapy as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-Small Cell Lung Cancer

A Phase II, Single-Arm, Prospective Study of Neoadjuvant Icotinib With Chemotherapy for the Treatment of Patients With Epidermal Growth Factor Receptor Mutation Positive, Resectable for Stage II to IIIB(N2) Non-small Cell Lung Cancer


Sponsor

Peking University Cancer Hospital & Institute

Enrollment

27 participants

Start Date

Oct 25, 2021

Study Type

INTERVENTIONAL

Summary

This is a Phase II, single-Arm, prospective study of neoadjuvant Icotinib with chemotherapy for the treatment of patients with epidermal growth factor receptor mutation positive, resectable for stage II to IIIB(N2) Non-small Cell Lung Cancer


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing icotinib (an EGFR-targeted drug) combined with chemotherapy as a pre-surgery treatment for people with early-stage lung adenocarcinoma that carries a specific EGFR gene mutation. **You may be eligible if...** - You are 18 years or older - You have lung adenocarcinoma confirmed by biopsy within the past 60 days - Your cancer is at clinical stage IIA, IIB, IIIA, or IIIB and is considered surgically removable - Your cancer has a common EGFR mutation (exon 19 deletion or exon 21 L858R) - You have not yet received any treatment for this lung cancer **You may NOT be eligible if...** - Your cancer does not have an EGFR mutation - Your tumor is too advanced to be surgically removed - You have previously received any EGFR-targeted therapy or other cancer treatments - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGIcotinib

Oral

DRUGCisplatin

Cisplatin (75mg/m2) to be administered with pemetrexed on Day 1 of every 3-week cycle for 2 cycles.

DRUGCarboplatin

Carboplatin (AUC5) to be administered with pemetrexed on Day 1 of every 3-week cycle for 2 cycles

DRUGPemetrexed

Pemetrexed (500 mg/m2) to be administered with cisplatin or carboplatin on Day 1 of every 3-week cycle for 2 cycles


Locations(1)

BeijingCancerH

Beijing, China

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT05104788