Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough

This study is comparing two doses of two medications — duloxetine and amitriptyline — both used for nerve-related conditions, to find the most effective treatment for people with a persistent cough that hasn't responded to standard treatments (called refractory or unexplained chronic cough). **You may be eligible if...** - You have had a persistent cough for at least 1 year that has not responded to standard treatment - Your cough severity is rated at least 40mm on a standard visual scale - A chest X-ray or CT scan within the last year shows no major lung abnormality explaining your cough - You are willing to use adequate contraception if you could become pregnant **You may NOT be eligible if...** - Your cough is explained by a significant lung condition - You have had the cough for less than 1 year - Your cough severity is below the minimum threshold - You are pregnant, breastfeeding, or unable to use birth control during the study Talk to your doctor to see if this trial is right for you.