RecruitingNot ApplicableNCT05131035

Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk

Targeting Processing Speed Deficits to Improve Social Functioning and Lower Psychosis Risk in Adolescents at Clinical High Risk for Psychosis

Sponsor

Northwell Health

Enrollment

54 participants

Start Date

Oct 28, 2021

Study Type

INTERVENTIONAL

Conditions

Psychosis Prodromal Symptoms Prodromal Schizophrenia

Summary

This 10 week intervention, Specific Cognitive Remediation with Surround (or SCORES), is designed to target processing speed, a cognitive domain related directly to social functioning, which in turn, represents a vulnerability factor for psychosis. This remotely-delivered intervention combining targeted cognitive training exercises and group support was developed to directly impact processing speed, and at the same time, boost motivation and engagement in adolescents at risk for schizophrenia and other psychotic disorders.

Eligibility

Min Age: 14 YearsMax Age: 20 Years

Plain Language Summary

Simplified for easier understanding

This study tests a brain-training program to improve mental processing speed in young people who show early warning signs of psychosis, with the goal of improving their social functioning and reducing their risk of developing a full psychotic disorder. **You may be eligible if...** - You meet criteria for "clinical high risk" for psychosis (experiencing mild psychosis-like symptoms) - You show signs of slower-than-average mental processing speed **You may NOT be eligible if...** - You already have a schizophrenia-spectrum diagnosis - You do not speak English - You have a significant neurological condition (e.g., epilepsy) - Your estimated IQ is below 70 Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALSCORES (Specific COgnitive Remediation with Support)

This study evaluates the effectiveness of a 10-week cognitive remediation program plus group coaching and therapy to improve processing speed and, in turn, social functioning and attenuated positive symptoms in CHR subjects. The SCORES (Specific COgnitive Remediation with Support) intervention is a novel CR program combined with group coaching, performance-based rewards, game-like tasks, and therapy elements to increase engagement and retention. In the 2 year, R61 phase, all participants will complete 40 hours of CR (4 hrs per week) with a mid-point assessment (20 hours of CR at 5 weeks) to determine the impact of CR on processing speed as measured by the MCCB. The second phase of the study (R33) will compare the 40 hours of speeded brain training to 40 hours of non-speeded brain training. This three year study will allow for a replication and assessment of specificity of the targeted intervention.