RecruitingNCT05132517

Magnesium and Cognition After Stroke

Relationship Between Magnesium Concentration in Blood and Kognitive Functions After Stroke

Sponsor

BDH-Klinik Hessisch Oldendorf

Enrollment

80 participants

Start Date

Oct 26, 2022

Study Type

OBSERVATIONAL

Conditions

Stroke Neurologic Disorder Cognition Magnesium

Summary

Cognitive impairments such as memory impairments, word-finding difficulties, compromised orientation and perception are often observed in stroke patients. Low serum-mg-concentrations are associated with cognitive impairments in ischemic stroke patients one month after stroke onset. It is not clear, if cognitive impairments after stroke is caused by the mg-deficiency or by the stroke itself. Until now, no studies investigating the relationship between mg-concentration, stroke severity and cognition during treatment course are available. Thus, this study aimed to investigate the relationship between mg-concentration and cognition of stroke patients.

Eligibility

Min Age: 18 Years

Inclusion Criteria2

ischemic/hemmorhagic stroke
written consent form

Exclusion Criteria5

pre-existing dementia or cognitive impairment before stroke onset
pre-existing mental disorder (depression) or present/prior long-term treatment (> 6 months) with psychotropic drugs
pre-existing malign tumor disease
participation in another clinical trial within the past 30 days
pregnancy or breastfeeding

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Interventions

DIAGNOSTIC_TESTKölner Neuropsychologische Screening für Schlaganfall-Patienten

The cognitive state of the patient is measure by the Kölner Neuropsychologische Screening (KöpSS) and by the Mini Mental Status Test (MMST). The MMST is a popular often used test, which makes comparisons to other international studies possible. However, even though this test was specifically designed for stroke patients, it has a limited sensibility. Thus the KöpSS is being used as an additional test demonstrating satisfactory sensibility and specificity. It is suitable for acute and subacute strokes and covers all stroke relevant domains.