Multiple Intracerebral Doses of Neural Stem Cell-Based Virotherapy (NSC-CRAd-S-pk7) for the Treatment of Recurrent High-Grade Gliomas

This study uses specially engineered stem cells to deliver a cancer-killing virus directly into brain tumors (high-grade gliomas, including glioblastoma) that have come back after prior treatment. **You may be eligible if...** - You are 18 or older - You have a Karnofsky performance score of 70% or more (able to care for yourself) - Your life expectancy is at least 3 months - You have glioblastoma at first recurrence (for the current treatment schedule) **You may NOT be eligible if...** - Your tumor is not a high-grade glioma or glioblastoma - You are in poor overall health or have a Karnofsky score below 70% - Your life expectancy is less than 3 months Talk to your doctor to see if this trial is right for you.