RecruitingPhase 2Phase 3NCT05166343

POHCA Resuscitation: Evaluation of IM Epinephrine

Pediatric Out-of-Hospital Cardiac Arrest Resuscitation: Evaluation of IM Epinephrine (The PRIME Trial)

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Enrollment

284 participants

Start Date

Jan 8, 2024

Study Type

INTERVENTIONAL

Conditions

Pediatric Out-of-Hospital Cardiac Arrest

Summary

This is a pragmatic, two-arm, open-label, prospective stepped-wedge cluster quasi randomized control trial (SW-CRCT) looking to evaluate early intramuscular (IM) epinephrine in the management of pediatric out-of-hospital cardiac arrest (POHCA).

Eligibility

Min Age: 1 DayMax Age: 17 Years

Inclusion Criteria2

Children aged 1 day to and including 17 years experiencing an out-of-hospital cardiac arrest (OHCA)
Must be receiving at least 1 minute of CPR by trained first responders (police, fire, or paramedic services)

Exclusion Criteria1

\- Children who experience OHCA due to an obvious traumatic event.

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Interventions

DRUGEpinephrine Injection

Epinephrine administered via sterile epinephrine injection USP, by 0.3mg or 0.5mg epinephrine auto-injector(s) and/or pre-filled syringe (exact dose).

Locations(1)

Children's Hospital - London Health Sciences Centre

London, Ontario, Canada

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NCT05166343