RecruitingNot ApplicableNCT05186116

LDLT in Non Resectable Colo-rectal Cancer Liver Metastasis

Living Donor Liver Transplantation (LDLT) in Non Resectable Colo-rectal Cancer Liver Metastasis. The LIVERMORE Trial (LIVing Donor livEr tRansplant Modena cOloRectal mEtastasis) [Original Title in Italian: "Trapianto di Fegato da Donatore Vivente Per Metastasi Epatiche Non Resecabili da Adenocarcinoma Del Colon"]


Sponsor

Azienda Ospedaliero-Universitaria di Modena

Enrollment

25 participants

Start Date

Jan 1, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This study is an interventional open label prospective study that aims to assess both overall and disease-free survival of patients treated with LDLT, partial or whole graft LT from deceased donors for unresectable CRLM. Secondary outcomes are graft survival and donor outcomes in terms of safety and quality of life. Donor selection is performed according to the currently used Institutional and National standards and protocols.


Eligibility

Min Age: 18 YearsMax Age: 77 Years

Plain Language Summary

Simplified for easier understanding

This trial is investigating whether a living-donor liver transplant can be a curative option for patients with colorectal cancer that has spread only to the liver and cannot be surgically removed from the liver alone. **You may be eligible if...** - You are 18 or older with confirmed colorectal cancer that has spread to the liver only - Your original colorectal tumor has been fully removed - Your liver cancer cannot be surgically removed - Your cancer has responded to chemotherapy and remained stable for at least 4 months - You are in good general health (ECOG 0–2) - There is no spread outside the liver **You may NOT be eligible if...** - You have a hereditary colorectal cancer syndrome (such as Lynch syndrome or FAP) - Your cancer has spread outside the liver or your original tumor has returned - You have another active cancer - You have active HIV infection - You have active alcohol or intravenous drug abuse - Your cancer is progressing despite treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURELiving donor liver transplant, Split liver transplant, RAPID, DDLT

Transplantation of part of the liver from a living donor, or entire cadaveric graft


Locations(1)

Azienda Ospedaliero Universitaria di Modena

Modena, MO, Italy

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NCT05186116


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