RecruitingNot ApplicableNCT05187819

Blood-based Biomarkers for Diagnosis of Alzheimer's

Accuracy of Blood-based Biomarkers in Diagnosing Alzheimer's Disease in Clinical Practice

Sponsor

Helse Stavanger HF

Enrollment

300 participants

Start Date

Jun 1, 2023

Study Type

INTERVENTIONAL

Conditions

Dementia Alzheimers

Summary

Alzheimer's disease (AD) may currently be diagnosed using molecular biomarkers in cerebrospinal fluid (CSF) and/or positron emission tomography (PET). These diagnostic procedures are highly accurate, but the high cost and low availability hamper their feasibility. Recently, ultrasensitive blood tests predicting Alzheimer pathologies in the brain have been developed. These tests have a reliable ability to differentiate AD from other neurodegenerative disorders and identify AD across the clinical continuum with high sensitivity and specificity in research cohorts with a high prevalence of AD. This project will assess the predictive value of these tests in a general practice population. The hypothesis is that the actual blood panel will have high positive predictive value for a diagnosis of Alzheimer's disease in the primary health care setting.

Eligibility

Min Age: 40 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating whether blood tests — specifically new blood-based biomarkers — can help diagnose Alzheimer's disease and other forms of dementia earlier and more accurately, potentially replacing the need for more invasive tests. **You may be eligible if...** - Your GP suspects you may have dementia based on your symptoms, history, or a cognitive screening test **You may NOT be eligible if...** - You do not have the mental capacity to consent to participation - You have severe psychiatric illness or take medications that might significantly affect your cognition for reasons unrelated to dementia - You do not want to be referred to a memory clinic for further assessment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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