Niclosamide in Pediatric Patients With Relapsed and Refractory AML

This trial is testing niclosamide — an antiparasitic drug being repurposed — in children and young adults with relapsed or treatment-resistant acute myeloid leukemia (AML) who have run out of other effective options. **You may be eligible if...** - You are between 2 and 30 years old with confirmed AML - Your cancer has come back or failed to respond to at least 2 rounds of intensive chemotherapy (or 4 rounds of non-intensive therapy) - You have not previously been treated with niclosamide - Your organ function is within acceptable ranges - You are able to take oral or tube-fed medication **You may NOT be eligible if...** - You have a specific leukemia subtype called acute promyelocytic leukemia (APL) - You have active brain (central nervous system) leukemia that is not being treated - You have a bleeding disorder or uncontrolled infection - You are currently pregnant or breastfeeding - You have active hepatitis C Talk to your doctor to see if this trial is right for you.