Radiotherapy for Locally Advanced Pancreatic Carcinomas (Phase II Trial)

This Phase II trial is studying the use of radiation therapy in patients with locally advanced pancreatic cancer that cannot be surgically removed and is no longer responding to, or not eligible for, chemotherapy. The goal is to determine whether radiation can help control the disease. **You may be eligible if...** - You are over 18 years old with confirmed pancreatic cancer that cannot be surgically removed - Your cancer has not spread to distant organs - You are no longer a candidate for chemotherapy (due to disease progression or poor tolerance) - Your overall health score (Karnofsky index) is 70 or above **You may NOT be eligible if...** - Your cancer has spread to other organs beyond the pancreas - You have a non-pancreatic exocrine tumor - You have had prior abdominal radiation therapy - You are pregnant or breastfeeding - You have severe liver or kidney impairment Talk to your doctor to see if this trial is right for you.