Evaluation of Macroscopic Muscle Growth in Infants and Young Children With Spastic Cerebral Palsy
The Integration of Macroscopic and Microscopic Muscle Properties With Cell Modelling to Feature Altered Neuromuscular Behavior in Cerebral Palsy: 3D-Macroscopic Muscle Architecture in Cerebral Palsy
Universitaire Ziekenhuizen KU Leuven
229 participants
Feb 11, 2019
OBSERVATIONAL
Conditions
Summary
A mixed longitudinal design study will be carried out to explore the onset and time course of morphological muscle changes on a macroscopic level in children with spastic cerebral palsy (SCP). Therefore, this project aims to (1) describe the macroscopic morphological muscle changes with increasing age and (2) evaluate the onset and development of muscle alterations in relation to the brain lesion (e.g., timing, extent and location), to the neuromuscular impairments and to treatment. Overall, this project will evaluate the macroscopic muscle properties by means of 3D freehand ultrasound (3DfUS).
Eligibility
Inclusion Criteria2
- Confirmed diagnosis of spastic cerebral palsy or patients at high-risk for spastic cerebral palsy
- Suspected GMFCS levels I-III (GMFCS = Gross Motor Function Classification Scale, expressing the overall functional level of impairment)
Exclusion Criteria7
- Non-ambulatory
- Botulinum neurotoxin type-A injections six months prior to enrollment
- Lower limb surgery two years prior to enrollment
- Muscle surgery at the muscles in the lower limb
- Selective dorsal rhizotomy as treatment history
- Presence of ataxia or dystonia
- Severe co-morbidities (severe epilepsy, severe behavior problems that impede the cooperation)
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT05197764