RecruitingNot ApplicableNCT05197881

Daily Adaptive Radiation Therapy an Individualized Approach for Carcinoma of the Cervix

Daily Adaptive External Beam Radiation Therapy in the Treatment of Carcinoma of the Cervix: A Prospective Trial of an Individualized Approach for Intestinal Toxicity Reduction (ARTIA-Cervix)


Sponsor

Varian, a Siemens Healthineers Company

Enrollment

125 participants

Start Date

May 3, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single-arm, prospective, multi-center clinical trial designed to demonstrate that adaptive radiotherapy for locally advanced cervical cancer will translate into a decreased rate of acute gastrointestinal toxicity compared with the historically reported rate for non-adaptive intensity modulated radiation therapy (IMRT). The timepoint for this assessment will be at week 5 of external beam radiotherapy (EBRT) and will use the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE).


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a more personalized, daily-adjusted form of radiation therapy for advanced cervical cancer. Instead of the same radiation plan every day, the plan is updated based on how the tumor changes during treatment to better target the cancer and protect healthy tissue. **You may be eligible if...** - You have been newly diagnosed with advanced cervical cancer (stages IB2–IVA) - Your cancer is squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma - You have not had a hysterectomy - You do not have cancer that has spread to the lymph nodes above the main abdominal aorta - You are planned to receive radiation therapy combined with chemotherapy **You may NOT be eligible if...** - Your cancer has spread to distant organs - You have had a prior hysterectomy - Your cancer involves lymph nodes in the upper abdomen (above the aortic bifurcation) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEVarian Ethos Adaptive Radiation Therapy

Daily adaptive external beam radiation therapy delivered on Varian Ethos treatment system.


Locations(5)

University of Alabama Birmingham

Burmingham, Alabama, United States

University of Arkansas Medical Sciences

Little Rock, Arkansas, United States

Moores Cancer Center at UC San Diego Health

La Jolla, California, United States

Fox Chase Cancer Center

Philadelphia, Pennsylvania, United States

University of Texas Southwestern

Dallas, Texas, United States

View Full Details on ClinicalTrials.gov

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NCT05197881


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