RecruitingNot ApplicableNCT05198076

6 Month Follow up Study on the Changes of Postural Stability in Parkinsonian Patients in Response to High Frequency TMS.

The Long Term Efficacy of High Frequency Repetitive Transcranial Magnetic Stimulation on Postural Stability in Parkinsonian Patients.

Sponsor

Cairo University

Enrollment

40 participants

Start Date

Jul 23, 2025

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease

Summary

Postural instability is one of the cardinal signs in Parkinson's disease (PD). It represents one of the most disabling symptoms in the advanced stages of the disease. It is associated with frequent falls and loss of independence. The aim of the current study is to assess the long term efficacy of high frequency repetitive transcranial magnetic stimulation (rTMS) on improving postural instability in PD patients.

Eligibility

Sex: MALEMin Age: 55 YearsMax Age: 70 Years

Inclusion Criteria6

All included patients should fulfill the U.K Parkinson's Disease Brain Bank Criteria for idiopathic PD.
Patients with mild to moderate disease severity according to UPRS and Modified Hoehn and Yahr staging
Duration of illness from two to five years were included.
All included patients should be medically and psychologically stable and of adequate cardiac function.
All included patients should haven't receive any rTMS sessions before.
Signed consent form should be taken from all included patients.

Exclusion Criteria2

Patients with implanted devices, serious medical illness or history of seizures were excluded.
Patients with severe freezing phenomenon or severe tremors were excluded

Interventions

DEVICEHigh Frequency Repetitive Transcranial Magnetic Stimulation

The High Frequency repetitive TMS will be delivered to the scalp over the primary motor cortex contralateral to the more affected side using a MAGSTIM rapid2 machine (Model P/N 3576-23-09, MAGSTIM Company LTD, UK) connected with a figure - of- eight shaped coil. Each patient will receive 12 sessions over four weeks. Position of the coil will be adjusted to find the optimal scalp position and the location of stimulation that will be marked to maintain consistency among sessions. The session will consist of 24 trains of 50 stimuli each delivered at five Hz. The procedure will be conducted with the patients in the ''On'' state (75 min. after medications)