RecruitingNot ApplicableNCT05198076

6 Month Follow up Study on the Changes of Postural Stability in Parkinsonian Patients in Response to High Frequency TMS.

The Long Term Efficacy of High Frequency Repetitive Transcranial Magnetic Stimulation on Postural Stability in Parkinsonian Patients.

Sponsor

Cairo University

Enrollment

40 participants

Start Date

Jul 23, 2025

Study Type

INTERVENTIONAL

Conditions

Parkinson Disease

Summary

Postural instability is one of the cardinal signs in Parkinson's disease (PD). It represents one of the most disabling symptoms in the advanced stages of the disease. It is associated with frequent falls and loss of independence. The aim of the current study is to assess the long term efficacy of high frequency repetitive transcranial magnetic stimulation (rTMS) on improving postural instability in PD patients.

Eligibility

Sex: MALEMin Age: 55 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is examining whether a type of brain stimulation called repetitive transcranial magnetic stimulation (rTMS — a non-invasive treatment using magnetic pulses) can improve balance and stability in patients with Parkinson's disease, and tracking results over 6 months. **You may be eligible if...** - You have been diagnosed with Parkinson's disease (idiopathic) - Your disease is mild to moderate in severity - You have had symptoms for 2 to 5 years - You are medically and psychologically stable - You have never received rTMS treatment before **You may NOT be eligible if...** - You have an implanted medical device (e.g., pacemaker) - You have a history of seizures - You have severe balance or tremor problems - You have a serious medical illness Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEHigh Frequency Repetitive Transcranial Magnetic Stimulation

The High Frequency repetitive TMS will be delivered to the scalp over the primary motor cortex contralateral to the more affected side using a MAGSTIM rapid2 machine (Model P/N 3576-23-09, MAGSTIM Company LTD, UK) connected with a figure - of- eight shaped coil. Each patient will receive 12 sessions over four weeks. Position of the coil will be adjusted to find the optimal scalp position and the location of stimulation that will be marked to maintain consistency among sessions. The session will consist of 24 trains of 50 stimuli each delivered at five Hz. The procedure will be conducted with the patients in the ''On'' state (75 min. after medications)