Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection
Hospices Civils de Lyon
3,500 participants
Aug 2, 2022
INTERVENTIONAL
Conditions
Summary
Numerous neurological disorders affecting the central and peripheral nervous system can be attributed to the immune system through multiple effector mechanisms. However, current treatments could be drastically improved by faster and more accurate diagnosis. The sample collection will benefit to patients with rare neuroimmune syndromes such as Autoimmune Encephalitis (AE) and Paraneoplastic Neurological Syndromes (PNS) leading to a better and early diagnosis, as well as treatment improvement.
Eligibility
Inclusion Criteria3
- Patient with consent
- Patient with well-characterized antibodies in serum or cerebrospinal fluid or not
- Patient with neurological disorder compatible with PNS or auto-immune encephalitis
Exclusion Criteria2
- Refusal of consent
- Patient under guardianship
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Interventions
Blood is collected only one time by blood sample to obtain serum, buffy coat, plasma and PBMC. 2 \*4ml of blood on dry tube 2 \*4ml of blood on EDTA tube If possibility of delivery in 48 hours at the Centre of Biological Resources, 7\*4ml of blood on heparin tube If cerebrospinal fluid has been drawn for diagnosis, remaining sample available will be stored in the collection
Locations(62)
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NCT05198661